A former child model who conveniently plays an ex-model-turned-med-student on Grey's Anatomy, Heigl started acting as a teen. Initially she focused on the big screen (My Father the Hero, Under Siege 2), but at 21 she signed on to the sci-fi TV series Roswell. After the series ended in 2002, she appeared in a number of TV-movies before striking small-screen gold on Grey's Anatomy as an emotionally overwrought doc, a turn that earned her an Emmy in 2007. That same year, she starred in the comedy Knocked Up as an ambitious career woman who gets pregnant after a one-night stand with a schlubby loser. The film turned out to be a sleeper hit, which gave her career another boost and led to her alternating between television and film roles. In 2009, she and husband Josh Kelley adopted a daughter named Nancy Leigh, and Heigl enjoys spending her downtime hanging out with her family.
Katherine Heigl Fast Facts:
Has played a character named Isabel (or Isobel) three times: Roswell (1999), Wuthering Heights (2003) and Grey's Anatomy (2005).
Interests include dancing, knitting, needlepoint, art and cooking.
Beat out Alicia Silverstone for the role of Nicole in the movie My Father, the Hero.
Became an advocate for organ donation after her brother Jason died of brain injuries in a car accident.
Had her Los Angeles home featured on Entertainment Tonight and HGTV.
Auditioned for ABC's Lost before she landed a lead role on Grey's Anatomy.
Criticized her character in Knocked Up for portraying women as "humorless and uptight."
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